If you are about to embark on a migration from Exchange 2003 to Exchange 2010 I highly recommend reading this blog Exchange 2003 to 2010 transition and download the PDF created by the people at msexchangegeek.com.
If you still have Outlook 2003 in your environment, you will find some good tips in this article Exchange 2010 with Outlook 2003.
Finally, don’t forget to visit the TechNet- Exchange 2010 Planning Guide.
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